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Is it possible to use a 'source' file that has what items to replace with what new text and run that file against the file you want the items replaced in?

Example:

Source File
text1;text2
text9; text8

Us that source file to search & replace in another file?

no, with textpad this is not possible.
http://www.textpad.com/products/wildedit/index.html might do what you want

another possibility is
http://www.softpedia.com/get/System/Fil ... ceEm.shtml

woho