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Found this in the Known Problems section as well: On Windows 2000 and XP, TextPad will freeze if you right click an associated file in the Open File dialog box, and choose Open from the context menu. This is due to a known problem in Windows. To avoid it, simply select the file and click the Open ...

This seems to have fixed it for me.
Change the registry key in

HKEY_CLASSES_ROOT\applications\TextPad.exe\shell\open\command

From
"C:\Program Files\TextPad 5\TextPad.exe" -s "%1"
To
"C:\Program Files\TextPad 5\TextPad.exe" "%1"

I get the error "Cannot find the file xxxx.xxx or one of its components.... "when trying to open a file from windows explorer or winzip. However the file actually opens fine; it just displays the error message. Any ideas why? I'm running textpad 5.0.3 I'd post a screen shot, but I'm not sure how...